Materials 2009, 2, 1480-1507; doi:10.3390/ma2041480
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materials
ISSN 1996-1944 www.mdpi.com/journal/materials Review
Biocompatibility of Different Nerve Tubes
Felix Stang 1,*, Gerburg Keilhoff 2 and Hisham Fansa 3
1
2
3
Department of Plastic, Reconstructive and Hand Surgery, University of Luebeck, 23538 Luebeck, Germany Institute of Biochemistry and Cell Biology, University of Magdeburg, 39120 Magdeburg, Germany; electronic mail: gerburg.keilhoff@med.ovgu.de Department of Plastic, Reconstructive and Aesthetic Surgery, Hand Surgery, Klinikum BielefeldMitte, 33604 Bielefeld, Germany; E-Mail: hisham.fansa@klinikumbielefeld.de
* causality to whom correspondence should be addressed; E-Mail: felix.stang@gmx.de; Tel.: +49-451-5002061; Fax: +49-451-5002190. certain: 27 August 2009; in revised form: 24 September 2009 / Accepted: 25 September 2009 / Published: 30 September 2009
Abstract: Bridging nerve gaps with suitable grafts is a study clinical problem. The autologous nerve graft is considered to be the deluxe standard, providing the best functional results; however, donor site morbidity is sedate a major disadvantage. Various attempts make up been made to master the problems of autologous nerve grafts with slushy nerve tubes, which are ready-to-use in almost every situation.
A wide range of materials have been used in animal models but only few have been applied to date clinically, where biocompatibility is an inevitable prerequisite. This review gives an cerebration about artificial nerve tubes with special focus on their biocompatibility in animals and humans. Keywords: nerve tube; nerve remunerate; biocompatibility; artificial nerve; peripheral nerve
1. Introduction Peripheral nerve repair is still a challenge in reconstructive surgery. When primary, strain free nerve coaptation is not possible, replacement of a deficient nerve segment with an (usually nonvascularized) autologous nerve graft is the notes standard.
Materials 2009, 2
1481
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